Perspectives

Choosing the Right Economic Model to Demonstrate Value for Tumor-Agnostic Therapies
Therapies designed to target cancers with specific molecular signatures have reshaped the landscape of oncological drug development.1 As the next generation of tumor-agnostic therapies make their way through clinical trials, we should be asking ourselves what we can do to prepare for the upcoming challenge of reimbursement in this space, and what lessons can be learnt from the experience of existing therapies. Over the coming months we will provide recommendations from our own experience and a review of the experiences of the tropomyosin receptor kinase (TRK) inhibitors (larotrectinib and entrectinib) on how to overcome the common challenges in this space in five short papers. Here, we look at what to consider when developing economic models of tumor-agnostic therapies, with a particular focus on the role of genetic testing in this space.
Whitepaper Feb 7, 2022